The RPA Interacting Protein Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to HRIP. This antibody recognizes Human, Mouse, and Rat antigen. The RPA Interacting Protein Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Replication protein A (RPA) is a single-stranded-DNA binding protein involved in numerous eukaryotic DNA processes including replication, repair and recombination. RPA interacting protein (RPA IP) has been identified as an adapter protein that is involved in RPA nuclear import instead of the prototypical importin proteins that normally mediate nuclear import. Multiple isoforms of RPA IP are known to exist, with the longest isoform localized to the cytoplasm. Isoform 2 is sumoylated and is located in the PML nuclear body within the nucleus. It has been suggested that this isoform mediates the localization of the RPA complex into the PML nuclear body, thereby participating in RPA function in DNA metabolism